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FTO-dependent m6A regulates muscle fiber remodeling in an NFATC1–YTHDF2 dependent manner

5 Jul 2023

Abstract excerpt

BACKGROUND: Adolescent idiopathic scoliosis (AIS) is characterized by low lean mass without vertebral deformity. The cause-and-effect relationship between scoliosis and paraspinal muscle imbalance has long puzzled researchers. Although FTO has been identified as a susceptibility gene for AIS, its potential role in the asymmetry of paraspinal muscles has not been fully elucidated. METHODS: A reader. Deep...

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PMID: 37408034
DOI: 10.1186/s13148-023-01526-5

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