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Article

Role of differentially expressed LBX1 in Adolescent Idiopathic Scoliosis (AIS) paraspinal muscle phenotypes and muscle-bone crosstalk through modulating myoblasts.

Studies in health technology and informatics - 28 Jun 2021

Wang Y, Feng Z, Cheng K L, Zhang J, Xu L, Lam T P, Hung Alh, Cheng Jcy, Qiu Y, Lee Wyw

Abstract excerpt

AIS is three-dimensional spinal deformity with unclear etiopathogenesis. LBX1 is so far the only multi-centers validated AIS predisposing gene. The imbalance of posterior paraspinal muscles is an important factor in AIS etiopathogenesis. It is poorly understood how LBX1 contributes to the abnormal paraspinal muscles and onset/progression of AIS. We aimed to evaluate the expression of LBX1 in paraspinal muscles at...

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PMID: 34190053
DOI: 10.3233/SHTI210425

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