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ZCCHC3 is a stress granule zinc knuckle protein that strongly suppresses LINE-1 retrotransposition

5 Jul 2023

Abstract excerpt

Retrotransposons have generated about half of the human genome and LINE-1s (L1s) are the only autonomously active retrotransposons. The cell has evolved an arsenal of defense mechanisms to protect against retrotransposition with factors we are only beginning to understand. In this study, we investigate Zinc Finger CCHC-Type Containing 3 (ZCCHC3), a gag-like zinc knuckle protein recently reported to function in...

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PMID: 37405998
DOI: 10.1371/journal.pgen.1010795

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