Article
ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA.
Molecular cell - 19 Mar 2026
Squair Daniel R, Rivers Eilidh, Sowar Hanna, Balci Arda, Harmo Roosa, Wright David J, Beniwal Gaurav, Soetens Mathieu, Mathur Sunil, Tollervey Aidan, Wood Nicola T, Pao Kuan-Chuan, Stanton Callum, Fletcher Adam J, Virdee Satpal
Abstract excerpt
The detection of viral RNA inside cells triggers a diverse range of antiviral responses, including global translation inhibition, interferon secretion, and RNA sequestration. Mutations in the gene zinc-finger NFX1-type containing 1 (ZNFX1) cause severe pediatric immunodeficiencies, including chronic viral infection and autoinflammation. Here, we show that ZNFX1 is an RNA helicase with cryptic and unusual...
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