Article

ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA

2025-09-05

Abstract excerpt

The detection of viral RNA inside cells triggers a diverse range of antiviral responses, including global translation inhibition, interferon secretion and RNA sequestration. Mutations in the gene ZNFX1 cause severe paediatric immunodeficiencies, including chronic viral infection and autoinflammation. Here, we show that ZNFX1 is an RNA helicase with cryptic and unusual bifurcating E3 ubiquitin ligase activity. Nuc...

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Literature Corpus work: a524a61f-0a6c-5edd-8956-189dfc6b1de3
DOI: 10.1101/2025.09.05.674436

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