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Article

Relationship between SHP2 gene polymorphisms and systemic lupus erythematosus risk.

International journal of rheumatic diseases - 1 Aug 2023

Li Rong, Zhou Ling, Yang Chan, Xu Wang-Dong, Huang An-Fang

Abstract excerpt

OBJECTIVE: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder. SHP2, a non-transmembrane member of the protein tyrosine phosphatase (PTP) family, can be involved in multiple signaling pathways in inflammatory response. To date, it remains to be investigated whether polymorphisms in the SHP2 gene are correlated with SLE in the Chinese Han population. METHOD: A study comprising 320 SLE patients and...

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PMID: 37270672
DOI: 10.1111/1756-185X.14761

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