Genetic susceptibility to systemic sclerosis from clinical aspect to genetic factor analyses.

doi:10.1016/j.ejim.2008.07.012

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Article

Genetic susceptibility to systemic sclerosis from clinical aspect to genetic factor analyses.

European journal of internal medicine - 1 May 2009

Granel Brigitte, Bernard Fanny, Chevillard Christophe

Abstract excerpt

BACKGROUND: Systemic sclerosis is a rare autoimmune disease mainly characterized by vascular alteration and fibrosis involving skin but also visceral organs such as lungs, digestive tract, and heart. This disease leads to high morbidity and mortality. Its pathogenesis remains unclear, but recent attention has focus on genetic factors. OBJECTIVE: We first recall the main manifestations associated with systemic...

Topics

Genetic Predisposition to Disease
Humans
Polymorphism, Genetic
Risk Factors
Scleroderma, Systemic

Source

Open in PubMed

Identifiers

PMID: 19393491
DOI: 10.1016/j.ejim.2008.07.012

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