Article
Incidence and prognostic impact of U2AF1 mutations and other gene alterations in myelodysplastic neoplasms with isolated 20q deletion.
Cancer medicine - 1 Aug 2023
Castillo Martín I, Ribate Villamón E, Muñoz Calabuig M, Santillana Sanz G, Taboada Such E, Casterá Mora E, Abinzano Calasanz M J, Barranco Irigoyen A, Nieto Collado R, Pampliega Vara M, Blanco M L, de Andrés Álvarez S, de Oteyza Pérez J, Del Castillo Bernal T, Font Granada I, Cayuela Jerez A, Díez-Campelo M, Sánchez Abellán R, Vercet Solano C, Díaz Tormo M
Abstract excerpt
BACKGROUND: In myelodysplastic neoplasms (MDS), the 20q deletion [del(20q)] is a recurrent chromosomal abnormality that it has a high co-occurrence with U2AF1 mutations. Nevertheless, the prognostic impact of U2AF1 in these MDS patients is uncertain and the possible clinical and/or prognostic differences between the mutation type and the mutational burden are also unknown. METHODS: Our study analyzes different...
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