Article
Clinical features and biological implications of different U2AF1 mutation types in myelodysplastic syndromes.
Genes, chromosomes & cancer - 1 Feb 2018
Li Bing, Liu Jinqin, Jia Yujiao, Wang Jingya, Xu Zefeng, Qin Tiejun, Shi Zhongxun, Song Zhen, Peng Shuailing, Huang Huijun, Fang Liwei, Zhang Hongli, Pan Lijuan, Hu Naibo, Qu Shiqiang, Zhang Yue, Wu Jian, Liu Na, Ru Kun, Huang Gang, Xiao Zhijian
Abstract excerpt
U2AF1 mutations (U2AF1MT) occur commonly in myelodysplastic syndromes (MDS) without ring sideroblasts. The aim of this study was to investigate the clinical and biological implications of different U2AF1 mutation types in MDS. We performed targeted gene sequencing in a cohort of 511 MDS patients. Eighty-six patients (17%) were found to have U2AF1MT, which occurred more common in younger patients (P = .001) and...
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