Article
The significance of genetic mutations and their prognostic impact on patients with incidental finding of isolated del(20q) in bone marrow without morphologic evidence of a myeloid neoplasm.
Blood cancer journal - 23 Jan 2020
Ravindran Aishwarya, He Rong, Ketterling Rhett P, Jawad Majd D, Chen Dong, Oliveira Jennifer L, Nguyen Phuong L, Viswanatha David S, Reichard Kaaren K, Hoyer James D, Go Ronald S, Shi Min
Abstract excerpt
Patients with a sole del(20q) chromosomal abnormality and without morphologic features of a myeloid neoplasm (MN) have shown variable clinical outcomes. To explore the potential risk stratification markers in this group of patients, we evaluated their genetic mutational landscape by a 35-gene MN-focused next-generation sequencing (NGS) panel and examined the association of mutations to progression of MNs. Our...
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