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ASXL1 mutations in AML are associated with specific clinical and cytogenetic characteristics.

Leukemia & lymphoma - 1 Oct 2018

Kakosaiou Katerina, Panitsas Fotios, Daraki Aggeliki, Pagoni Maria, Apostolou Paraskevi, Ioannidou Agapi, Vlachadami Ioanna, Marinakis Theodoros, Giatra Chara, Vasilatou Diamantina, Sambani Constantina, Pappa Vassiliki, Manola Kalliopi N

Abstract excerpt

Mutations of ASXL1 are early events in acute myeloid leukemia (AML) leukemogenesis and have been associated with unfavorable prognosis. In this study, we investigated the type and frequency of ASXL1 mutations in a large cohort of patients with de novo or secondary AML (s-AML) and looked for correlations with cytogenetic findings and disease features. ASXL1 mutations were associated with older age, s-AML and...

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Identifiers

PMID: 29411666
DOI: 10.1080/10428194.2018.1433298

Genes

ASXL1

Variants

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