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Article

The NSP6-L260F substitution in SARS-CoV-2 BQ.1.1 and XBB.1.16 lineages compensates for the reduced viral polymerase activity caused by mutations in NSP13 and NSP14.

Journal of virology - 17 Jun 2025

Furusawa Yuri, Iwatsuki-Horimoto Kiyoko, Yamayoshi Seiya, Kawaoka Yoshihiro

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants emerged at the end of 2021, and their subvariants are still circulating worldwide. While changes in the S protein of these variants have been extensively studied, the roles of amino acid substitutions in non-structural proteins have not been fully revealed. In this study, we found that SARS-CoV-2 bearing the NSP6-L260F substitution...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40358207
DOI: 10.1128/jvi.00656-25
PMCID: PMC12172475

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