Article
HLA-A23/HLA-A24 serotypes and dementia interaction in the elderly: Association with increased soluble HLA class I molecules in plasma.
HLA - 1 Dec 2023
Cardoso Elsa M, Lourenço-Gomes Vânia, Esgalhado André J, Reste-Ferreira Débora, Oliveira Nádia, Amaral Ana Saraiva, Martinho António, Gama Jorge M R, Verde Ignácio, Lourenço Olga, Fonseca Ana M, Buchli Rico, Arosa Fernando A
Abstract excerpt
MHC class I molecules regulate brain development and plasticity in mice and HLA class I molecules are associated with brain disorders in humans. We investigated the relationship between plasma-derived soluble human HLA class I molecules (sHLA class I), HLA class I serotypes and dementia. A cohort of HLA class I serotyped elderly subjects with no dementia/pre-dementia (NpD, n = 28), or with dementia (D, n = 28)...
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