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Stepwise Evolution of E. coli C and ΦX174 Reveals Unexpected Lipopolysaccharide (LPS) Diversity.

Molecular biology and evolution - 5 Jul 2023

Romeyer Dherbey Jordan, Parab Lavisha, Gallie Jenna, Bertels Frederic

Abstract excerpt

Phage therapy is a promising method for the treatment of multidrug-resistant bacterial infections. However, its long-term efficacy depends on understanding the evolutionary effects of the treatment. Current knowledge of such evolutionary effects is lacking, even in well-studied systems. We used the bacterium Escherichia coli C and its bacteriophage ΦX174, which infects cells using host lipopolysaccharide (LPS)...

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PMID: 37399035
DOI: 10.1093/molbev/msad154
PMCID: PMC10368449

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