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Article

Coevolutionary phage training leads to greater bacterial suppression and delays the evolution of phage resistance.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jun 2021

Borin Joshua M, Avrani Sarit, Barrick Jeffrey E, Petrie Katherine L, Meyer Justin R

Abstract excerpt

The evolution of antibiotic-resistant bacteria threatens to become the leading cause of worldwide mortality. This crisis has renewed interest in the practice of phage therapy. Yet, bacteria's capacity to evolve resistance may debilitate this therapy as well. To combat the evolution of phage resistance and improve treatment outcomes, many suggest leveraging phages' ability to counter resistance by evolving phages...

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Identifiers

PMID: 34083444
DOI: 10.1073/pnas.2104592118
PMCID: PMC8201913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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