Article
Experimental Evolution of the TolC-Receptor Phage U136B Functionally Identifies a Tail Fiber Protein Involved in Adsorption through Strong Parallel Adaptation.
Applied and environmental microbiology - 28 Jun 2023
Burmeister Alita R, Tzintzun-Tapia Eddy, Roush Carli, Mangal Ivan, Barahman Roxanna, Bjornson Robert D, Turner Paul E
Abstract excerpt
Bacteriophages have received recent attention for their therapeutic potential to treat antibiotic-resistant bacterial infections. One particular idea in phage therapy is to use phages that not only directly kill their bacterial hosts but also rely on particular bacterial receptors, such as proteins involved in virulence or antibiotic resistance. In such cases, the evolution of phage resistance would correspond to...
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