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Article

Pleiotropy complicates a trade-off between phage resistance and antibiotic resistance.

Proceedings of the National Academy of Sciences of the United States of America - 26 May 2020

Burmeister Alita R, Fortier Abigail, Roush Carli, Lessing Adam J, Bender Rose G, Barahman Roxanna, Grant Raeven, Chan Benjamin K, Turner Paul E

Abstract excerpt

Bacteria frequently encounter selection by both antibiotics and lytic bacteriophages. However, the evolutionary interactions between antibiotics and phages remain unclear, in particular, whether and when phages can drive evolutionary trade-offs with antibiotic resistance. Here, we describe Escherichia coli phage U136B, showing it relies on two host factors involved in different antibiotic resistance mechanisms:...

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Share to Bacterial Outer Membrane Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32424102
DOI: 10.1073/pnas.1919888117
PMCID: PMC7260982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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