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Article

Construction and evaluation of the functional polygenic risk score for gastric cancer in a prospective cohort of the European population.

Chinese medical journal - 20 Jul 2023

Gu Yuanliang, Yan Caiwang, Wang Tianpei, Hu Beiping, Zhu Meng, Jin Guangfu

Abstract excerpt

BACKGROUND: A polygenic risk score (PRS) derived from 112 single-nucleotide polymorphisms (SNPs) for gastric cancer has been reported in Chinese populations (PRS-112). However, its performance in other populations is unknown. A functional PRS (fPRS) using functional SNPs (fSNPs) may improve the generalizability of the PRS across populations with distinct ethnicities. METHODS: We performed functional annotations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37394533
DOI: 10.1097/CM9.0000000000002716
PMCID: PMC10344526

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