Article
Heme-Induced Macrophage Phenotype Switching and Impaired Endogenous Opioid Homeostasis Correlate with Chronic Widespread Pain in HIV.
Cells - 6 Jun 2023
Chatterjee Tanima, Arora Itika, Underwood Lilly B, Lewis Terry L, Masjoan Juncos Juan Xavier, Heath Sonya L, Goodin Burel R, Aggarwal Saurabh
Abstract excerpt
Chronic widespread pain (CWP) is associated with a high rate of disability and decreased quality of life in people with HIV-1 (PWH). We previously showed that PWH with CWP have increased hemolysis and elevated plasma levels of cell-free heme, which correlate with low endogenous opioid levels in leukocytes. Further, we demonstrated that cell-free heme impairs β-endorphin synthesis/release from leukocytes. However,...
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