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Article

Wounding the Immune System with its Own Blade: HIV-Induced Tryptophan Catabolism and Pathogenesis

1 May 2011

Abstract excerpt

Indoleamine 2,3-dioxygenase (IDO) is an immunoregulatory enzyme which plays a key role in maintaining the physiologic immune balance between the efficient responses to insulting pathogens and the control of harmful autoimmune reactions. During HIV infection, multiple mechanisms involving both viral and cellular components, contribute to enhance IDO expression and activity in an uncontrolled manner. The downstream...

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PMID: 21517754
DOI: 10.2174/092986711795656126

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