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Cannabis use by people with HIV is associated with an anti-inflammatory immunometabolic phenotype in monocyte-derived macrophages.

Journal of neuroinflammation - 17 Apr 2026

Ford Mary K, Halcrow Peter W, Laird Anna E, Avalos Bryant L, Boustani Ali, Spencer Matthew, Melcher Jack I, Walter Kyle C, Hong Derek D, Funk Gail, Searson Elizabeth G, Le Alexandra A, Ellis Ronald J, Letendre Scott, Marcondes Maria Cecilia Garibaldi, Schlachetzki Johannes Cm, Iudicello Jennifer, Fields Jerel Adam

Abstract excerpt

Chronic neuroinflammation is associated with comorbidities in people with HIV (PWH) on antiretroviral therapy (ART). While cannabis use is associated with reduced neuroinflammation and neurocognitive impairment (NCI) in PWH, the underlying mechanisms are unknown. To address this gap in knowledge, we analyzed monocyte-derived macrophages (MDMs) from a cohort of 50 PWH and 33 people without HIV (mean age:...

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Cohort Studies
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BDNF gene

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PMID: 41998680
DOI: 10.1186/s12974-026-03779-2
PMCID: PMC13214123

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BDNF

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