Article
Lysis and phenotypic modulation of mesenchymal stromal cells upon blood contact triggers anti-inflammatory skewing of the peripheral innate immune repertoire.
Cytotherapy - 1 Sept 2023
Davies Lindsay C, Queckbörner Suzanna, Jylhä Cecilia E, Andrén Anton Törnqvist, Forshell Tacha Zi Plym, Blanc Katarina Le
Abstract excerpt
BACKGROUND AIMS: Mesenchymal stromal cells (MSCs) are used to treat immune-related disorders, including graft-versus-host disease. Upon intravenous infusion, MSCs trigger the instant blood-mediated inflammatory response, resulting in activation of both complement and coagulation cascades, and are rapidly cleared from circulation. Despite no/minimal engraftment, long-term immunoregulatory properties are evident....
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