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Article

Efferocytosis of viable versus heat-inactivated MSC induces human monocytes to distinct immunosuppressive phenotypes.

Stem cell research & therapy - 17 Aug 2023

Schrodt Michael V, Behan-Bush Riley M, Liszewski Jesse N, Humpal-Pash Madeleine E, Boland Lauren K, Scroggins Sabrina M, Santillan Donna A, Ankrum James A

Abstract excerpt

BACKGROUND: Immunomodulation by mesenchymal stromal cells (MSCs) can occur through trophic factor mechanisms, however, intravenously infused MSCs are rapidly cleared from the body yet a potent immunotherapeutic response is still observed. Recent work suggests that monocytes contribute to the clearance of MSCs via efferocytosis, the body's natural mechanism for clearing dead and dying cells in a non-inflammatory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37592321
DOI: 10.1186/s13287-023-03443-z
PMCID: PMC10433682

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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