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Article

Human mesenchymal stem cells shift CD8+ T cells towards a suppressive phenotype by inducing tolerogenic monocytes.

Journal of cell science - 1 Oct 2012

Hof-Nahor Irit, Leshansky Lucy, Shivtiel Shoham, Eldor Liron, Aberdam Daniel, Itskovitz-Eldor Joseph, Berrih-Aknin Sonia

Abstract excerpt

The mechanisms underlying the immunomodulatory effects of mesenchymal stem cells (MSCs) have been investigated under extreme conditions of strong T cell activation, which induces the rapid death of activated lymphocytes. The objective of this study was to investigate these mechanisms in the absence of additional polyclonal activation. In co-cultures of peripheral mononuclear blood cells with human MSCs (hereafter...

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Share to CD8 Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22767507
DOI: 10.1242/jcs.108860

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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