Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tau Mutations Serve as a Novel Risk Factor for Cancer.

Cancer research - 1 Jul 2018

Rossi Giacomina, Redaelli Veronica, Contiero Paolo, Fabiano Sabrina, Tagliabue Giovanna, Perego Paola, Benussi Luisa, Bruni Amalia C, Filippini Graziella, Farinotti Mariangela, Giaccone Giorgio, Buiatiotis Simona, Manzoni Claudia, Ferrari Raffaele, Tagliavini Fabrizio

Abstract excerpt

In addition to its well-recognized role in neurodegeneration, tau participates in maintenance of genome stability and chromosome integrity. In particular, peripheral cells from patients affected by frontotemporal lobar degeneration carrying a mutation in tau gene (genetic tauopathies), as well as cells from animal models, show chromosome numerical and structural aberrations, chromatin anomalies, and a propensity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Biology
Share to Frontotemporal Lobar Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Instability

Share to Incidence

Share to Neoplasms

Share to Pedigree

Share to Protein Interaction Maps

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 29794074
DOI: 10.1158/0008-5472.CAN-17-3175
PMCID: PMC6031304

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tau Mutations Serve as a Novel Risk Factor for Cancer.PMID 29794074Read ↗

Cancer-specific association between Tau ( <i>MAPT</i> ) and cellular pathways, clinical outcome, and drug responseSemantic proximity Read ↗

Emerging Evidences for an Implication of the Neurodegeneration-Associated Protein TAU in CancerSemantic proximity Read ↗

Pathogenic tau disrupts the cellular program that maintains neuronal identitySemantic proximity Read ↗

P301L tau mutation leads to alterations of cell cycle, DNA damage response and apoptosis: Evidence for a role of tau in cancer.Semantic proximity Read ↗

Frontotemporal lobar degeneration: old knowledge and new insight into the pathogenetic mechanisms of tau mutationsSemantic proximity Read ↗

Tau Protein as Therapeutic Target for Cancer? Focus on GlioblastomaSemantic proximity Read ↗

Novel Functions of the Neurodegenerative-Related Gene Tau in CancerSemantic proximity Read ↗

Mutations in MAPT gene cause chromosome instability and introduce copy number variations widely in the genome.Semantic proximity Read ↗

Tau and DNA Damage in NeurodegenerationSemantic proximity Read ↗

A new function of microtubule-associated protein tau: involvement in chromosome stability.Semantic proximity Read ↗

Alzheimer’s disease and related tauopathies: disorders of disrupted neuronal identitySemantic proximity Read ↗

DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer’s, Related Tauopathies and Genetic TauopathiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.