Article
Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck cancer.
Epigenetics - 1 Jul 2014
Guerrero-Preston Rafael, Michailidi Christina, Marchionni Luigi, Pickering Curtis R, Frederick Mitchell J, Myers Jeffrey N, Yegnasubramanian Srinivasan, Hadar Tal, Noordhuis Maartje G, Zizkova Veronika, Fertig Elana, Agrawal Nishant, Westra William, Koch Wayne, Califano Joseph, Velculescu Victor E, Sidransky David
Abstract excerpt
Tumor suppressor genes (TSGs) are commonly inactivated by somatic mutation and/or promoter methylation; yet, recent high-throughput genomic studies have not identified key TSGs inactivated by both mechanisms. We pursued an integrated molecular analysis based on methylation binding domain sequencing (MBD-seq), 450K Methylation arrays, whole exome sequencing, and whole genome gene expression arrays in primary head...
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