Characterization of the Nasopharyngeal Carcinoma Methylome Identifies Aberrant Disruption of Key Signaling Pathways and Methylated Tumor Suppressor Genes

Abstract excerpt

AIMS: Nasopharyngeal carcinoma (NPC) is a common tumor consistently associated with Epstein-Barr virus infection and prevalent in South China, including Hong Kong, and southeast Asia. Current genomic sequencing studies found only rare mutations in NPC, indicating its critical epigenetic etiology, while no epigenome exists for NPC as yet. MATERIALS & METHODS: We profiled the methylomes of NPC cell lines and...

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