Article
Excitatory Amino acid transporter expression in the essential tremor dentate nucleus and cerebellar cortex: A postmortem study.
Parkinsonism & related disorders - 1 Nov 2016
Wang Jie, Kelly Geoffrey C, Tate William J, Li Yong-Shi, Lee Michelle, Gutierrez Jesus, Louis Elan D, Faust Phyllis L, Kuo Sheng-Han
Abstract excerpt
BACKGROUND: Genome-wide association studies have revealed a link between essential tremor (ET) and the gene SLC1A2, which encodes excitatory amino acid transporter type 2 (EAAT2). We explored EAAT biology in ET by quantifying EAAT2 and EAAT1 levels in the cerebellar dentate nucleus, and expanded our prior analysis of EAAT2 levels in the cerebellar cortex. OBJECTIVE: To quantify EAAT2 and EAAT1 levels in the...
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