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Article

Bias reduction improves accuracy and informativity of high-throughput sequencing chimerism assays.

Clinica chimica acta; international journal of clinical chemistry - 1 Jul 2023

Vynck Matthijs, Nollet Friedel, Sibbens Lode, Devos Helena

Abstract excerpt

BACKGROUND AND AIMS: Chimerism monitoring by means of high-throughput sequencing of biallelic polymorphisms has shown promising advantages for patient follow-up after hematopoietic stem cell transplantation. Yet, the presence of method bias precludes achievement of an assay's theoretically attainable informativity rate, as method bias necessitates the exclusion of some markers. This method bias arises because of...

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Identifiers

PMID: 37343694
DOI: 10.1016/j.cca.2023.117452

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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