Article
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis.
Nature - 14 Apr 2005
Bartkova Jirina, Horejsí Zuzana, Koed Karen, Krämer Alwin, Tort Frederic, Zieger Karsten, Guldberg Per, Sehested Maxwell, Nesland Jahn M, Lukas Claudia, Ørntoft Torben, Lukas Jiri, Bartek Jiri
Abstract excerpt
During the evolution of cancer, the incipient tumour experiences 'oncogenic stress', which evokes a counter-response to eliminate such hazardous cells. However, the nature of this stress remains elusive, as does the inducible anti-cancer barrier that elicits growth arrest or cell death. Here we show that in clinical specimens from different stages of human tumours of the urinary bladder, breast, lung and colon,...
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