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Article

Cell contractility drives mechanical memory of oral squamous cell carcinoma

21 Jun 2023

Abstract excerpt

Matrix stiffening is ubiquitous in solid tumors and can direct epithelial-mesenchymal transition (EMT) and cancer cell migration. Stiffened niche can even cause poorly invasive oral squamous cell carcinoma (OSCC) cell lines to acquire a less adherent, more migratory phenotype, but mechanisms and durability of this acquired "mechanical memory" are unclear. Here, we observed that contractility and its downstream...

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PMID: 37342880
DOI: 10.1091/mbc.e22-07-0266

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