Article

Breast tumor stiffness instructs bone metastasis via mechanical memory

2019-11-20

Abstract excerpt

The mechanical microenvironment of primary breast tumors plays a substantial role in promoting tumor progression. While the transitory response of cancer cells to pathological stiffness in their native microenvironment has been well described, it is still unclear how mechanical stimuli in the primary tumor influence distant, late-stage metastatic phenotypes across time and space in absentia. Here, we show that pri...

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Literature Corpus work: 54f9d2c1-fcb7-5779-9e67-8cbe701c239f
DOI: 10.1101/847699

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