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Article

Adhesion strength and contractility enable metastatic cells to become adurotactic.

Cell reports - 9 Mar 2021

Yeoman Benjamin, Shatkin Gabriel, Beri Pranjali, Banisadr Afsheen, Katira Parag, Engler Adam J

Abstract excerpt

Significant changes in cell stiffness, contractility, and adhesion, i.e., mechanotype, are observed during a variety of biological processes. Whether cell mechanics merely change as a side effect of or driver for biological processes is still unclear. Here, we sort genotypically similar metastatic cancer cells into strongly adherent (SA) versus weakly adherent (WA) phenotypes to study how contractility and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33691109
DOI: 10.1016/j.celrep.2021.108816
PMCID: PMC7997775

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