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Article

Matrix Stiffness Drives Aggressive Phenotype in Tongue Squamous Cell Carcinoma via Mechanotransduction-Stromal Signalling.

International dental journal - 1 Aug 2026

Tiskratok Watcharaphol, Kyawsoewin Maythwe, Thuephut Rachadol, Ketkrathok Kansuda, Leerahakanch Chichaya, Chanwises Patipan, Jitprasertwong Paiboon, Yamada Masahiro, Egusa Hiroshi, Limraksasin Phoonsuk

Abstract excerpt

OBJECTIVES: Tongue squamous cell carcinoma (TSCC) is a highly aggressive malignancy where extracellular matrix (ECM) stiffening drives epithelial-mesenchymal transition (EMT). However, the specific mechanotransduction pathways and the distinction between primary and metastatic cell responses remain insufficiently defined. This study investigated how substrate stiffness regulates TSCC progression via a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42035719
DOI: 10.1016/j.identj.2026.109581
PMCID: PMC13134031

Genes

HGF
CDH2
MMP2
VIM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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