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Article

Polydom/SVEP1 binds to Tie1 and promotes migration of lymphatic endothelial cells

6 Jun 2023

Abstract excerpt

Polydom is an extracellular matrix protein involved in lymphatic vessel development. Polydom-deficient mice die immediately after birth due to defects in lymphatic vessel remodeling, but the mechanism involved is poorly understood. Here, we report that Polydom directly binds to Tie1, an orphan receptor in the Angiopoietin-Tie axis, and facilitates migration of lymphatic endothelial cells (LECs) in a...

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PMID: 37338522
DOI: 10.1083/jcb.202208047

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