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Article

An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation.

Circulation research - 14 Apr 2017

Karpanen Terhi, Padberg Yvonne, van de Pavert Serge A, Dierkes Cathrin, Morooka Nanami, Peterson-Maduro Josi, van de Hoek Glenn, Adrian Max, Mochizuki Naoki, Sekiguchi Kiyotoshi, Kiefer Friedemann, Schulte Dörte, Schulte-Merker Stefan

Abstract excerpt

RATIONALE: Lymphatic vessel formation and function constitutes a physiologically and pathophysiologically important process, but its genetic control is not well understood. OBJECTIVE: Here, we identify the secreted Polydom/Svep1 protein as essential for the formation of the lymphatic vasculature. We analyzed mutants in mice and zebrafish to gain insight into the role of Polydom/Svep1 in the lymphangiogenic...

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Source

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Identifiers

PMID: 28179432
DOI: 10.1161/CIRCRESAHA.116.308813
PMCID: PMC5389596

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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