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Article

Prox1 Induces Lymphatic Endothelial Differentiation via Integrin α9 and Other Signaling Cascades

8 Feb 2007

Abstract excerpt

During embryonic lymphatic development, a homeobox transcription factor Prox1 plays important roles in sprouting and migration of a subpopulation of blood vessel endothelial cells (BECs) toward VEGF-C-expressing cells. However, effects of Prox1 on endothelial cellular behavior remain to be elucidated. Here, we show that Prox1, via induction of integrin alpha9 expression, inhibits sheet formation and stimulates...

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PMID: 17287396
DOI: 10.1091/mbc.e06-09-0780

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Prox1 Induces Lymphatic Endothelial Differentiation via Integrin α9 and Other Signaling CascadesPMID 17287396Read ↗

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