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Article

Transcriptomic classes of BCR-ABL1 lymphoblastic leukemia

19 Jun 2023

Abstract excerpt

Abstract In BCR-ABL1 lymphoblastic leukemia, treatment heterogeneity to tyrosine kinase inhibitors (TKIs), especially in the absence of kinase domain mutations in BCR-ABL1, is poorly understood. Through deep molecular profiling, we uncovered three transcriptomic subtypes of BCR-ABL1 lymphoblastic leukemia, each representing a maturation arrest at a stage of B-cell progenitor differentiation. An earlier arrest was...

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PMID: 37337105
DOI: 10.1038/s41588-023-01429-4

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