Article
A novel targeted RNA-Seq panel identifies a subset of adult patients with acute lymphoblastic leukemia with BCR-ABL1-like characteristics.
Blood cancer journal - 24 Apr 2020
Sánchez Ricardo, Ribera Jordi, Morgades Mireia, Ayala Rosa, Onecha Esther, Ruiz-Heredia Yanira, Juárez-Rufián Alexandra, de Nicolás Rodrigo, Sánchez-Pina José, Vives Susana, Zamora Lurdes, Mercadal Santiago, Coll Rosa, Cervera Marta, García Olga, Ribera Josep-Maria, Martínez-López Joaquín
Abstract excerpt
BCR-ABL1-like B-cell precursor acute lymphoblastic leukemia (BCP-ALL) remains poorly characterized in adults. We sought to establish the frequency and outcome of adolescent and adult BCR-ABL1-like ALL using a novel RNA-Seq signature in a series of patients with BCP-ALL. To this end, we developed and tested an RNA-Seq custom panel of 42 genes related to a BCR-ABL1-like signature in a cohort of 100 patients with...
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