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Developmental trajectories and cooperating genomic events define molecular subtypes of BCR::ABL1-positive ALL

28 Dec 2023

Abstract excerpt

ABSTRACT: Distinct diagnostic entities within BCR::ABL1-positive acute lymphoblastic leukemia (ALL) are currently defined by the International Consensus Classification of myeloid neoplasms and acute leukemias (ICC): "lymphoid only", with BCR::ABL1 observed exclusively in lymphatic precursors, vs "multilineage", where BCR::ABL1 is also present in other hematopoietic lineages. Here, we analyzed transcriptomes of...

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PMID: 38153913
DOI: 10.1182/blood.2023021752

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