Article
Mutation in crrB encoding a sensor kinase increases expression of the RND-type multidrug efflux pump KexD in Klebsiella pneumoniae.
Gene - 20 Aug 2023
Dodan Hayata, Hiromura Makoto, Ni Rui Ting, Matsubara Futoshi, Kuroda Teruo, Ogawa Wakano
Abstract excerpt
BACKGROUND: RND-type multidrug efflux systems in Gram-negative bacteria protect them against antimicrobial agents. Gram-negative bacteria generally possess several genes which encode such efflux pumps, but these pumps sometimes fail to show expression. Generally, some multidrug efflux pumps are silent or expressed only at low levels. However, genome mutations often increase the expression of such genes,...
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