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The role of RND-type efflux pumps in multidrug-resistant mutants of Klebsiella pneumoniae

2 Jul 2020

Abstract excerpt

Abstract The emergence of multidrug-resistant Klebsiella pneumoniae is a worldwide problem. K. pneumoniae possesses numerous resistant genes in its genome. We isolated mutants resistant to various antimicrobials in vitro and investigated the importance of intrinsic genes in acquired resistance. The isolation frequency of the mutants was 10−7–10−9. Of the multidrug-resistant mutants, hyper-multidrug-resistant...

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PMID: 32616840
DOI: 10.1038/s41598-020-67820-x

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