Identifying Escherichia coli genes involved in intrinsic multidrug resistance.

doi:10.1007/s00253-008-1709-6

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Article

Identifying Escherichia coli genes involved in intrinsic multidrug resistance.

Applied microbiology and biotechnology - 1 Dec 2008

Duo Miao, Hou Shuyu, Ren Dacheng

Abstract excerpt

Multidrug resistance is a major cause of clinical failure in treating bacterial infections. Increasing evidence suggests that bacteria can resist multiple antibiotics through intrinsic mechanisms that rely on gene products such as efflux pumps that expel antibiotics and special membrane proteins that block the penetration of drug molecules. In this study, Escherichia coli was used as a model system to explore the...

Topics

Anti-Bacterial Agents
Biofilms
Chloramphenicol
Drug Resistance, Multiple, Bacterial
Escherichia coli
Escherichia coli Proteins
Gene Library
Mutagenesis, Insertional
Mutation

Source

Open in PubMed

Identifiers

PMID: 18807027
DOI: 10.1007/s00253-008-1709-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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