Mendelian randomization analyses identify bidirectional causal relationships of obesity with psychiatric disorders.

Abstract excerpt

BACKGROUND: Obesity have been showed to be strongly associated with psychiatric disorders, but the exact causality and the direction of the relationship remain inconclusive. Thus, we aimed to identify the causal associations between obesity and psychiatric disorders using two-sample Mendelian randomization (MR). METHODS: Single-nucleotide polymorphisms associated with obesity, including body mass index (BMI),...

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• Attention Deficit Hyperactivity Disorder
• Depressive Disorder, Major
• Genetic Associations and Epidemiology
• Genome-Wide Association Study