Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AKAP12 promotes cancer stem cell-like phenotypes and activates STAT3 in colorectal cancer.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Nov 2023

Li Ke, Wu Xuan, Li Yuan, Hu Ting-Ting, Wang Weifeng, Gonzalez Frank J, Liu Weiwei

Abstract excerpt

BACKGROUND: Cancer stem cells (CSCs) have unique biological characteristics, including tumorigenicity, immortality, and chemoresistance. Colorectal CSCs have been identified and isolated from colorectal cancers by various methods. AKAP12, a scaffolding protein, is considered to act as a potential suppressor in colorectal cancer, but its role in CSCs remains unknown. In this study, we investigated the function of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to A Kinase Anchor Proteins
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Cell Proliferation

Share to Colorectal Neoplasms

Share to Neoplastic Stem Cells

Share to Phenotype

Share to STAT3 Transcription Factor

Source

Identifiers

PMID: 37326825
DOI: 10.1007/s12094-023-03230-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AKAP12 promotes cancer stem cell-like phenotypes and activates STAT3 in colorectal cancer.PMID 37326825Read ↗

Cancer stem cells in human gastrointestinal cancerSemantic proximity Read ↗

Cancer stem cells in colorectal cancer: a reviewSemantic proximity Read ↗

SKP1 promotes YAP-mediated colorectal cancer stemness via suppressing RASSF1Semantic proximity Read ↗

Targeting CDK12 obviates the malignant phenotypes of colorectal cancer through the Wnt/β-catenin signaling pathway.Semantic proximity Read ↗

STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH+/CD133+ stem cell-like human colon cancer cellsSemantic proximity Read ↗

SKP1 promotes YAP-mediated colorectal cancer stemness via suppressing RASSF1Semantic proximity Read ↗

AKAP-9 promotes colorectal cancer development by regulating Cdc42 interacting protein 4Semantic proximity Read ↗

Knock out CD44 in reprogrammed liver cancer cell C3A increases CSCs stemness and promotes differentiation.Semantic proximity Read ↗

Identification of autophagy-related genes for regulating cancer stem cell characteristics in colon adenocarcinoma by the analysis of transcriptome data stemness indicesSemantic proximity Read ↗

BAG3 regulates cell proliferation, migration, and invasion in human colorectal cancerSemantic proximity Read ↗

A mutant KRAS‐induced factor REG4 promotes cancer stem cell properties via Wnt/β‐catenin signalingSemantic proximity Read ↗

KCTD12 Regulates Colorectal Cancer Cell Stemness through the ERK PathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.