Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KCTD12 Regulates Colorectal Cancer Cell Stemness through the ERK Pathway

5 Feb 2016

Abstract excerpt

Targeting cancer stem cells (CSCs) in colorectal cancer (CRC) remains a difficult problem, as the regulation of CSCs in CRC is poorly understood. Here we demonstrated that KCTD12, potassium channel tetramerization domain containing 12, is down-regulated in the CSC-like cells of CRC. The silencing of endogenous KCTD12 and the overexpression of ectopic KCTD12 dramatically enhances and represses CRC cell stemness,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26847701
DOI: 10.1038/srep20460

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

KCTD12 Regulates Colorectal Cancer Cell Stemness through the ERK PathwayPMID 26847701Read ↗

Targeting CDK12 obviates the malignant phenotypes of colorectal cancer through the Wnt/β-catenin signaling pathway.Semantic proximity Read ↗

AKAP12 promotes cancer stem cell-like phenotypes and activates STAT3 in colorectal cancer.Semantic proximity Read ↗

The Role of KDM2B and EZH2 in Regulating the Stemness in Colorectal Cancer Through the PI3K/AKT PathwaySemantic proximity Read ↗

Embryonic Stem Cell-Related Protein L1TD1 Is Required for Cell Viability, Neurosphere Formation, and Chemoresistance in MedulloblastomaSemantic proximity Read ↗

Reduced CD146 expression promotes tumorigenesis and cancer stemness in colorectal cancer through activating Wnt/β-catenin signaling.Semantic proximity Read ↗

Two chemotherapeutic agents expand stem-like CD62L+CD8+ T cells in antitumor immune responsesSemantic proximity Read ↗

CDK8 Maintains Tumor Dedifferentiation and Embryonic Stem Cell PluripotencySemantic proximity Read ↗

KIF11 Is Required for Spheroid Formation by Oesophageal and Colorectal Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.