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Article

SKP1 promotes YAP-mediated colorectal cancer stemness via suppressing RASSF1

1 Dec 2020

Abstract excerpt

BACKGROUND: Cancer stem cells (CSCs) have been recognized as an important drug target, however, the underlying mechanisms have not been fully understood. SKP1 is a traditional drug target for cancer therapy, while, whether SKP1 promotes colorectal cancer (CRC) stem cells (CRC-SCs) and the underlying mechanisms have remained elusive. METHODS: Human CRC cell lines and primary human CRC cells were used in this...

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PMID: 33292299
DOI: 10.1186/s12935-020-01683-0

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