Article
Knock out CD44 in reprogrammed liver cancer cell C3A increases CSCs stemness and promotes differentiation.
Oncotarget - 29 Dec 2015
Han Shuo, Guo Jinhai, Liu Yinan, Zhang Zhi, He Qihua, Li Peng, Zhang Mingzhi, Sun Haojie, Li Ruizhi, Li Yang, Zeng Wotan, Liu Jinwen, Lian Lejian, Gao Yi, Shen Li
Abstract excerpt
CD44 is a widely known cancer stem cells marker in various cancers and validated to function in tumor growth, survival and tumor metastasis. In this study, we first established C3A-derived liver cancer stem cells by OSKM method [OCT4, SOX2, KLF4, and c-MYC], termed C3A-induced cancer stem cells (C3A-iCSCs) which acquired self-renewal and stemness abilities. Then we found CD44 was positive in C3A-iCSCs and mainly...
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