Article
The complementarity of DDR, nucleic acids and anti-tumour immunity.
Nature - 1 Jul 2023
Kornepati Anand V R, Rogers Cody M, Sung Patrick, Curiel Tyler J
Abstract excerpt
Immune checkpoint blockade (ICB) immunotherapy is a first-line treatment for selected cancers, yet the mechanisms of its efficacy remain incompletely understood. Furthermore, only a minority of patients with cancer benefit from ICB, and there is a lack of fully informative treatment response biomarkers. Selectively exploiting defects in DNA damage repair is also a standard treatment for cancer, spurred by...
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