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The DNA damage response in immunotherapy and radiation

1 Oct 2018

Abstract excerpt

PURPOSE: Deficiencies in DNA damage repair (DDR) and response represent a common alteration in tumors, and exploitation of this feature using therapeutics has become more prominent. METHODS AND MATERIALS: Recent work has highlighted the important interaction between DDR defects, as well as DDR targeting agents such as radiation and the immunogenicity of the tumor. This relationship emphasizes the potential for...

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PMID: 30370352
DOI: 10.1016/j.adro.2018.08.017

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